Динамика клинико-эндоскопических, морфологических и иммуногистохимических показателей у пациентов с гастроэзофагеальной рефлюксной болезнью, получающих полихимиотерапию

The aim of the study was to determine the role of molecules PCNA, Bcl-2, NF-Kb and tachykinins in the pathogenesis of gastroesophageal reflux disease (GERD) in patients receiving combination chemotherapy (PCT). The study involved 60 patients with GERD receiving combination chemotherapy Leukemia over standard dose for at least one year. Patients receiving PCT, the formation of GERD is associated with reduced expression of PCNA, neurokinin A high degree of expression of Bcl-2 and factor Nf-Kb, which explains the frequent detection of atrophic and metaplastic changes in the esophageal mucosa. It has been shown that administration of ursodeoxycholic acid in the complex therapy of GERD can overcome resistance to proton pump inhibitors and improve the performance of cell renewal of epithelial cells of the esophageal mucosa.