Optimal management of patients with stage I non-small-cell lung cancer and compromised cardiopulmonary function

SUMMARY Lobectomy with systematic lymph node evaluation is the standard of care for medically fit patients with stage I non-small-cell lung cancer. The definition of ‘medically inoperable’ has evolved over time as technological advances have reduced the morbidity and mortality associated with surgery. Operability is currently more appropriately described as a gradient of risk, rather than a strict characterization of inoperable versus operable. For patients who cannot tolerate a lobectomy, multiple treatment options exist: sublobar resection, fractionated radiation, stereotactic body radiation therapy (SBRT) and radiofrequency ablation. Ongoing randomized studies will provide direct comparisons of surgery versus SBRT for both standard- and high-risk operable patients. For medically inoperable patients, radiation is the standard of care, and SBRT offers high rates of local control with limited morbidity. Prospective trials will continue to inform, but in the meantime, the best approach is a multidisciplina...