PD23-11 DIAGNOSTIC ACCURACY OF CONTRAST-ENHANCED VOIDING UROSONOGRAM USING SECOND GENERATION CONTRAST WITH HARMONIC IMAGING (CEVUS-HI) IN THE DIAGNOSIS OF VESICOURETERAL REFLUX (VUR) IN CHILDREN: A META-ANALYSIS

INTRODUCTION AND OBJECTIVES:Vesicoureteral Reflux (VUR) is a common condition affecting 34.8 to 37.4% of all pediatric populations worldwide. Prompt diagnosis and adequate management is required to avoid serious long-term sequelae like renal failure. We aim to assess the diagnostic accuracy and safety of contrast enhanced urosonography using second generation contrast with harmonic imaging (CEVUS-HI) based on standard fluoroscopic voiding cystourethrogram (VCUG) in detecting VUR among children.METHODS:Literature search was performed on several medical databases on March 8, 2018. Comparative studies were independently screened and assessed by three reviewers. Study quality was appraised using QUADAS-2 tool. Diagnostic accuracy of sensitivity (Sn), Specificity (Sp), positive likelihood ratio (pLR), negative likelihood ratio (nLR) and diagnostic odds ratio (dOR) were determined with VCUG as the reference standard. Adverse effects were summarized. The inter study variability, and heterogeneity and its possibl...