In-house reference materials of mometasone furoate with traceable assay certified values

Characterization of in-house reference materials (IHRMs) with traceable property values for the mometasone furoate assay is discussed. The traceability of the value carried by the IHRM has been established to the value carried by a higher metrological status United States Pharmacopoeia Reference Standard (USP RS). A comparative approach is used to overcome systematic errors in measurement results, specific to the measurement method and/or to the laboratory developing the IHRM. The traceability chain was realized by the simultaneous analysis of the IHRM and the USP RS test portions under the same conditions.