The Osmoregulatory System and the Renin-Angiotensin-Aldosterone System in Pre-Eclampsia and Normotensive Pregnancy

Pedersen EB, Johannesen P, Rasmussen AB, Danielsen H. The osmoregulatory system and the renin-angiotensin-aldosterone system in pre-eclampsia and normotensive pregnancy. Scand J Clin Lab Invest 1985; 45: 627–633.Plasma concentrations of arginine vasopressin (AVP), angiotensin II (A II), aldosterone (Aldo), serum osmolality (Sosm), urine volume (V), and free water clearance (CH2o) were determined in the third trimester of pregnancy, and 5 days and 3 months after delivery in pre-eclampsia (group I), in normotensive pregnancy (group II), and in non-pregnant control subjects (group III). The AVP was the same in the third trimester of pregnancy in groups I and IT and did not deviate significantly from the level in group III. However, 5 days after delivery, AVP was lower and V and CH2o higher in group I than in group II. There was no correlation between AVP and Sosm in the third trimester in either group I or II, but 5 days after delivery a significant positive correlation was found between these parameters in ...