Efficacy of biologic agents (BA) in metastatic, triple-negative breast cancer (TNBC): A systematic review.

e11587 Background: TNBC accounts for about 15% of all invasive breast cancers, usually with an aggressive behavior and poor prognosis also because of lack of standard-of-care therapy. In this setting, BA in combination with chemotherapy (CT) may have a role, also based on TNBC cellular specific targets. Methods: To assess the role of BA in metastatic TNBC, a systematic review of randomized controlled trials published from January 2006 to January 2011 and of communications presented at ESMO, ASCO and SABCS congresses in 2009 and 2010 was performed. Only studies comparing BA+CT versus CT alone in TNBC, or in unspecified advanced breast cancer but presenting data on TNBC subgroup, were considered. The relevant statistical variables for the pooled analysis were the log of hazard ratio (HR) and relative variance for progression-free survival (PFS) and overall survival (OS). Results: Out of 346 Pubmed publications and 126 studies registered on http://clinicaltrial.gov, 8 trials were selected for analysis. A t...