COVID-19-Related Disseminated Leukoencephalopathy (CRDL): A Retrospective Study of Findings on Brain MRI.

Among 2,820 inpatients with coronavirus disease-2019 (COVID-19), 59 (2.1%) underwent brain MRI. Of these patients, six (10.2%) had findings on MRI suspicious for COVID-19 related disseminated leukoencephalopathy (CRDL), characterized by extensive confluent or multifocal white matter lesions (with characteristics and locations atypical for other etiologies), microhemorrhages, diffusion restriction, and enhancement. CRDL is an uncommon but important differential consideration in patients with neurologic manifestations of COVID-19.