Copper-catalyzed C–N coupling/C–H functionalization: A tandem approach to azole-fused quinazoline derivatives
2018
Abstract A Cu-catalyzed tandem synthesis of azole-fused pyrimido[1,2- c ]quinazolines and imidazo[1,2- c ]quinazolines has been developed. The reaction is based on a C–N cross-coupling/C–H functionalization reaction of 2-(2-bromophenyl)-1,4,5,6-tetrahydropyrimidines with azoles. A variety of the desired polycyclic products were obtained in moderate to excellent yields.
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