Double primary carcinoma of endometrial carcinoma and colorec- tal carcinoma: retrospective analysis of 34 cases and discussion of its relationship with Lynch syndrome

2 Pe- king Union Medical College, Beijing 100021, China Abstract Objective: To approach the clinicopathologic characteristics, treatment modalities, and prognosis of the patients with double primary carcinoma of endometrial carcinoma and colorectal carcinoma and analyze the relationship between this disease and Lynch syndrome. Methods: The clinicopathologic and follow-up data of 34 cases with double primary carcinoma of endometrial carci- noma and colorectal carcinoma treated in Cancer Hospital of Chinese Academy of Medical Sciences were reviewed. Results: The medi- an age of the 34 patients was 51.5 years old (ranging from 39 to 76). Twenty-two of the total cases (22/34, 64.7%) had tumor family his- tory. The pathologic results indicated that 79.4% (27/34) was endometrioid adenocarcinoma. In the 34 cases, 33 were treated by surgical procedure. Of the 33 cases undergoing surgery, 17 patients with endometrial carcinoma and 19 with colorectal carcinoma received fur- ther adjuvant treatment of chemotherapy and /or radiotherapy. The 2- and 5-year survival rates were 84.3% and 63.1% in the 34 cases, respectively. Conclusion: The age of onset is earlier in the patients with double primary carcinoma than in those with sporadic colorec- tal carcinoma. Some cases have cancer family history, and their survival rates are similar to those of the patients with sporadic colorec-