Corynebacterium pathogenic species in next-generation genomic era: the use of EDGAR and PIPS software and the importance of pathogenicity islands identification in pan-genomic analyses of pathogenic species

studies have been performed, focusing in: phylogenetics analyses and how those species correlate with each other; pan-genomics analyses and the degree of variability within the species; pathogenicity island identification, commonly shared virulence factors and how genome plasticity may influence the genomes of those species; and, reverse vaccinology and the identification of new canditate targets for future vaccine developments. In this chapter, we review the disease patterns of each species according to their hosts, the high potential of the methodologies and their resulting data, and the putative pathogenicity islands and candidate targets identified in