Highly sensitive and selective label-free detection of cardiac biomarkers in blood serum with silicon nanowire biosensors

Arrays of highly ordered silicon nanowire (SiNW) are fabricated using complementary metal-oxide semiconductor (CMOS) field effect transistor-compatible technology, and the ultrasensitive, label-free, electrical detection of cardiac biomarker in blood serum using the array sensor is demonstrated. The SiNW array biosensor allows for real-time detection of cardiac biomarker in desalted serum, more importantly, multiplexed detection of cardiac biomarkers in untreated and non-desalted blood serum.