Biochemical profile following partial hepatectomy in Wistar rats

The liver is an organ that plays a central role in maintaining metabolic homeostasis, in its functions of metabolism, synthesis and storage of nutrients. This study was conducted to evaluate the biochemical changes following partial hepatectomy in wistar rats. A total of twenty animals were subjected to partial hepatectomy under general anaesthesia and then were used to determine the changes in liver parenchymal enzymes like ALP, AST, ALT, γGT, total protein, albumin, bilirubin and blood glucose at various time intervals for a period of 40 days. The results were compared with normal values of animals prior to surgery. It was observed that after partial hepatectomy the levels of ALP, AST, ALT, γGT, bilirubin increased while the level of blood glucose, total protein and albumin level decreased.