Regiospecific synthesis of 1,4,5-trisubstituted 1,2,3-triazoles via enolate–azide cycloaddition between 1,3-dicarbonyl compounds and aryl azides

A cycloaddition reaction at room temperature between aryl azides and 1,3-dicarbonyl compounds in the presence of potassium carbonate in dimethylsulphoxide yielded 10 4-ethoxycarbonyl-1-aryl-5-methyl-1H-1,2,3-triazoles and seven other closely-related compounds. The 1,2,3-triazoles, nine of which are new, were obtained in good to high yields and only the 1,4-regioisomers were formed.