PO-073: Radiation Induced Liver Disease after Stereotactic Body Radiation Therapy for Small Hepatocellular Carcinoma : Risk Factor and Clinical Significance

Aims: The aim of this study was to identify parameters that predict radiation induced liver disease (RILD) following stereotactic body radiotherapy (SBRT) in cirrhotic patients with small hepatocellular carcinoma (HCC). Methods: We retrospectively reviewed 84 patients treated with SBRT for small (diameter <3 cm) HCC treated by SBRT between March 2011 and February 2015. RILD was defined as elevated liver transaminases more than five times the upper limit of normal or a worsening of Child-Pugh score by 2 within 3 months after SBRT. All patients were assessed at 1 month and every 3 months after SBRT. Results: Median follow-up was 16.5 (2-56) months after SBRT. Seventeen (18.5%) of the 84 patients developed RILD after SBRT. Multivariate logistic regression analysis showed that Child-Pugh (CP) scores (p < 0.01) was significant parameter to predict RILD in cirrhotic patients. According to linear by linear association model, as CP score increases, the incidence rate of RILD (P<0.01) increases, and the recov- ery rate of RILD (P<0.01) shows a tendency to decrease. The incidence rate of RILD increases at CP score 6 remarkably, and the recovery rate of RILD seems to decrease significantly at CP score 8. In multivariate analysis, CP score 8 was independent prognostic factors of overall survival. (P<0.01) Conclusions: CP score is important factor to predict RILD. The Incidence rate of RILD seems to increase, but does not recover at CP score above 8.