Zur Synthese und HPLC-Trennung atropisomerer und zentral chiraler 3-Aryl-2-mercapto- und 3-Aryl-2-alkylthio-4(3H)-chinazolinonderivate an chiralen stationären Phasen. Teil 2: Chirale Enantiomerentrennung

In this paper, the stereochemical resolution of atropisomeric and central chiral 3-aryl-2-mercapto-, 3-aryl-2-alkylthio-4(3H)-quinazolinones and their derivatives with chiral side chain on chiral stationary phases (CSP) are described. These CSP are a Pirkle phase (ChiralD-DPG=Si 100), a synthetic polymer (ChiraSpher®) and various types of cellulose (Chiralcel® OD-H, OD-R, Chiralcel®OB-H and cellulose triacetate (TAC) and other CSP. The cellulose phases gave the best results. The effects of the position and type of the substituent as well as the effect of the temperature and mobile phase composition on the chromatographic separation are described