Substituted naphthyridine-2-one compound, preparation method, use and pharmaceutical composition

The present invention provides a compound as represented by formula I, pharmaceutically acceptable salt, preparation method, use and pharmaceutical composition thereof. The compound represented by formula I is as follows:_(Formula I).The compound as represented by formula I has more excellent anti-cancer or anti-tumor effect, can inhibit various kinases inside cell and on cell surface simultaneously, and therefore has more efficient anti-cancer or anti-tumor effect, the kinases comprising PI3-K kinase and mTOR kinase. The pharmaceutical composition provided in the present invention can be used for treating cerebral cancer, glioblastoma, cervicocerebral cancer, lung cancer, melanoma, liver cancer, renal cancer, acute leukemia, chronic leukemia、non-small cell lung cancer、prostate cancer, thyroid cancer, skin cancer, colon cancer, rectal cancer, pancreatic cancer, ovarian cancer, breast cancer, myelodysplasia syndromes, esophageal cancer, sarcoma, osteosarcoma and rhabdomyoma.