Tumor lysis syndrome in a patient with ovarian yolk sac tumor

Ovarian yolk sac tumor is a subtype of germ cell tumor – a rare gynecologic malignancy comprising < 5% of all ovarian neoplasms (Shaaban et al., 2014). These tumors are characterized by high mitotic rates and rapid proliferation, often resulting in bulky tumor burden. Tumor lysis syndrome has been reported in association with germ cell tumors, typically following chemotherapy (Feres et al., 2008). Herein, we present the case of tumor lysis syndrome following low-dose, localized palliative radiation prior to chemotherapy exposure in a patient with a metastatic germ cell tumor.