Preeclampsia-associated homeostasis changes in pregnant woman after ART.

OBJECTIVE To determine the preeclampsia-associated features of homeostasis in pregnant woman after ART to clarify the possible mechanisms and factors of preeclampsia. DESIGN A prospective study. SETTING Department of Obstetrics, Gynecology and Reproductology, Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine. METHODS The 150 pregnant woman after ART were examined: 48 with preeclampsia (subgroup 1), 102 preeclampsia-free (subgroup 2). The liver enzymes in blood: alanine aminotransferase (ALT), aspartate aminotransferase (AST); the lipid metabolism indices: total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), aterogenity index (AI), triglycerides (TG), 25-hydroxy-vitamin D concentration, cytokines: interleukin-1, -2, -6, -8, -10 (IL-1, IL-2,, IL-6, IL-8, IL-10), tumor necrosis factor (TNF), number of platelets, platelet aggregate function, fibrinogen (F), activated partial thrombin time (aPTT), soluble fibrin monomer complexes (SFMC), D-dimer, von Willebrand factor (VWF) activity were measured. To compare the means Students t-test was used. RESULTS In women with preeclampsia, the transaminase levels and lipidogram indices (TG, LDL, LDL, AI) are elevated. Blood vitamin D are decreased (25.92±4.76 vs. 38.42±5.12 ng/mL, p.