Validation of Siemens T2* inline WIP package for quantification of cardiac and hepatic iron loading at 1.5T and 3T

Background The ability of T2* cardiovascular magnetic resonance (CMR) to identify cardiac iron loading has facilitated a dramatic reduction in mortality in patients with iron overload. There remains a worldwide need for improved access to iron evaluation. One route to achieving this would be simple in-line T2* analysis. We compared our validated T2* methods which use Royal Brompton Hospital (RBH) T2* sequences with analysis by CMRtools against a novel work-in-progress (WIP) sequence and inline T2* analysis. Methods 22 healthy volunteers and 78 patients were recruited (thalassaemia major 39, sickle cell disease 15, hereditary hemochromatosis 10, other iron overload conditions 14) who were referred for routine iron assessment (53 male, aged 13 to 81 years). A 1.5T study (MAGNETOM Avanto, Siemens AG Healthcare Sector, Erlangen, Germany) was performed on all subjects, from whom a subset of 50 underwent an additional 3T study (MAGNETOM Skyra). The same mid-ventricular short axis cardiac slice and transaxial slice through the liver were used to acquire both RBH T2* images and WIP T2* maps for each scan. Cardiac white blood (WB) and black blood (BB) sequences were acquired. All data acquisition and ROI based analysis was performed by a single observer. Results