Efficacy and Safety of Treatment of Ruptured Intracranial Aneurysms.

Objective To compare the treatment results of ruptured aneurysms treated endovascularly with aneurysms treated with microsurgical clipping. Methods This prospective multicenter study recorded and analyzed 661 cases of ruptured intracranial aneurysms with consecutive subarachnoid hemorrhage treated between 1997 and 2014 at 2 large medical centers. Endovascular treatment was performed in 271 cases, and microsurgical treatment was performed in 390 cases. The treatment modality was chosen by neuroradiologists and vascular neurosurgeons and was classified by predetermined decision criteria. Results Symptomatic ischemic stroke occurred in 46 patients (17.0%) in the endovascular group versus 26 patients (6.7%) in the microsurgery group (odds ratio [OR] = 2.86; 95% confidence interval [CI], 1.72–4.76; P P P  = 0.00085). No patient required retreatment in the microsurgery group, whereas 23 patients required retreatment in the endovascular group ( P P  = 0.21). Conclusions Microsurgical clipping shows a lower rate of treatment-associated complications and a higher occlusion rate of ruptured intracranial aneurysms than coil embolization. The individual evaluation and decision process for choice of treatment modality in this study is very effective.