Randomized Trial Comparing Netilmicin plus Imipenem-Cilastatin versus Netilmicin plus Ceftazidime as Empiric Therapy for Febrile Neutropenic Bone Marrow Transplant Recipients

AbstractThe aim of this study was to compare the clinical and microbiological efficacy of netilmicin plus imipenem-cilastatin (Net+Imi) vs netilmicin plus ceftazidime (Net+Cef) as empiric antimicrobial therapy in bone marrow transplant (BMT) febrile neutropenic patients (pts). Sixty-six pts undergoing BMT for hematological malignancies and solid tumors were randomized to receive Net+Imi or Net+Cef as first-line antibiotic therapy. A lasting return of temperature to normal and complete disappearance of either clinical or cultural signs of infection without any modification of therapy was considered as improvement; the persistence of fever after 72 hours, the addition of a third antibiotic or a protocol change was considered as failure. Sixty-nine episodes were randomized during the course of the trial; bacteriological evidence of infection was obtained in 17 (25%) febrile episodes. Overall outcome based on clinical responses was as follows: 80% of pts on Net+Imi responded compared to 73% of those on Net+Ce...