Potentiation of cisplatin-induced nephrotoxicity in rats by allopurinol.

Summary Cisplatin (CDDP) is an effective chemotherapeutic agent used against various human malignancies. However, it induces nephrotoxicity, a severe side effect in which oxygen free radicals have been implicated to play an important role. The effect of allopurinol (Allp) given in a dose of 50 mg/kg subcutaneously (sc) for five days was examined on induced nephrotoxicity by a single dose of 5 mg/kg CDDP intraperitoneally (ip) in male wistar rats. Serum creatinine and blood urea nitrogen (BUN) concentrations were found significantly higher in the group given both Allp and CDDP than in the group given CDDP alone, p