In vivo brain temperature measurements based on fiber optic Bragg grating

This work reports on the development of an optical fiber sensor based fiber Bragg Grating (FBG) probe for in vivo measurements of brain temperature. The major goal of this work is to demonstrate that the changes in brain temperature induced by drugs is an important reality, which could provide new valuable information on the mechanisms of drug action and open new therapeutic approaches. This probe can be interrogated using a portable optical measurement setup, allowing for measurements to be performed outside of standard optical laboratories.