Chronic Inhalation Exposure of Experimental Animals to Methylcyclohexane

Abstract : Four animal species were exposed for one year to selected vapor concentrations of methylcyclohexane (MCH) to determine its long-term toxic effects. Year-long exposures of animals were conducted to MCH at 0, 400, and 2000 ppm. Rats, mice, and hamsters were held for one year postexposure while dogs were held for five years postexposure. Mean body weight depression was observed in the MCH exposed hamsters and male rats. The only significant lesions noted in any of the animals was progressive renal nephropathy seen in virtually all of the male rats.