Safety and efficacy of pembrolizumab monotherapy in patients with advanced colorectal MSI-h/dMMR cancers.

Vasiliki Michalaki,Andreas Polydorou,Nikolaos Dafnios,Theodosios Theodosopoulos,Antonios Vezakis,Konstantinos Iliakopoulos,Despina Karandrea,Christos Papadimitriou

Safety and efficacy of pembrolizumab monotherapy in patients with advanced colorectal MSI-h/dMMR cancers.

2020

Vasiliki Michalaki
Andreas Polydorou
Nikolaos Dafnios
Theodosios Theodosopoulos
Antonios Vezakis
Konstantinos Iliakopoulos
Despina Karandrea
Christos Papadimitriou

e16010Background: Tumours that are deficient in DNA mismatch repair (dMMR) have high microsatellite instability (MSI-H) are likely to be immunogenic, triggering upregulation of immune checkpoint pr...

Keywords:

Oncology
Internal medicine
in patient
Pathology
Pembrolizumab
Medicine
Cancer research
Downregulation and upregulation
DNA mismatch repair
Immune checkpoint
Microsatellite instability

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