Organophosphorus compounds containing tetrazole heterocycle and synthetic method and application of organophosphorus compound
2015
The invention relates to organophosphorus compounds containing tetrazole heterocycle and a synthetic method and application of the organophosphorus compounds. The organophosphorus compounds containing tetrazole heterocycle provided by the invention are described in the general formula I and the general formula II. The preparation method comprises the following steps: reacting tetrazole with halide to generate multifarious substituted tetrazole III and IV; reacting substituted tetrazole III or IV with chloride phosphate compounds under the action of alkali, so as to obtain the organophosphorus compounds I and II containing tetrazole heterocycle. The invention provides an easy, feasible and novel method for synthesis of multifarious tetrazolium phosphate active compounds; the compounds required to be protected are not reported; the synthetic method provided by the invention is easy and feasible, and is applicable to preparation of multifarious small molecule compound library; the compounds are subjected to nematode disease activity related screening.
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