Synthesis and QSAR Study of 4-(6-methylquinolin-3-yl) - Dihydropyrimidines and their Antimicrobial and Antitubercular Activity

A new series of quinolone pyrimidines were synthesized employing cyclo-condensation reaction of quinolinyl chalcones with either urea or thiourea and their anti-microbial and anti-tubercular properties were examined. The preliminary studies indicate significant inhibition against two gram positive bacteria (Bacillus subtilis, Bacillus coccus), two gram negative bacteria (Escherichia coli, Proteus Vulgaris), fungi (Aspergillusniger) and Mycobacterium tuberculosis H37Rv. This study reports compound 4e as potential lead candidate for tuberculosis. The structural characteristics that affects the structure-activity relationship(SAR) was reported by implementing recursive partitioning (RP) analysis base classification model, which can be useful for further lead development.