MEN 2A Family- Prophylactic Thyroidectomy for Asymptomatic Siblings with Positive 634 Codon Mutation

Multiple endocrine neoplasia 2a (MeN2a) syndrome is one of the rare genetic disorder where prophylactic thyroidectomy is recommended for reT mutation carriers due to increased risk for developing MTC during lifetime. We present a case report of prophylactic total thyroidectomy in a family based on genetic screening that proved to be MTC on histopathology. This is the first reported case in India where siblings underwent codon oriented prophylactic total thyroidectomy based solely on genetic analysis for MeN2a syndrome.