1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT7 receptor ligands

Methvin Isaac,Tao Xin,Anne OBrien,David St. Martin,Angela Naismith,Neil Maclean,Julie Wilson,Lidia Demchyshyn,Ashok Tehim,Abdelmalik Slassi

1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT7 receptor ligands

2002

Methvin Isaac
Tao Xin
Anne OBrien
David St. Martin
Angela Naismith
Neil Maclean
Julie Wilson
Lidia Demchyshyn
Ashok Tehim
Abdelmalik Slassi

Abstract A novel series of 1-(bicyclopiperazinyl)ethylindole and 1-(homopiperazinyl)ethyl-indole derivatives was synthesized and found to be potent and selective 5-HT 7 receptor ligands.

Keywords:

Organic chemistry
Chemical synthesis
Bicyclic molecule
5-HT7 receptor
Biochemistry
Ligand
Receptor
Chemistry
In vitro
Stereochemistry
highly selective
Selectivity

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