The Expression of Hephaestine During Focal Cerebral Ischemia in Rats

Objective To study the expression of hephaestine during acute focal cerebral ischemia and reperfusion in rats. Methods The Expression of hephaestine in the cortex and striatum of rats during acute cerebral ischemia and reperfusion were investigated by using immunohistochemistry and computer image analysised. Results Hephaestine expression was observed in normal cortex and striatum of rats.With the ischemia and reperfusion time going on,the expression of hephaestine was obviously changed,peaked at the 12th and 24th hour (P0.01) after reperfusion,declined one week after(P0.01). Conclusion There was a change of expression of hephaestine in the cortex and striatum during acute cerebral ischemia and reperfusion,its mechanism of brain potecion remains unclear.