[Heidelberg Retina Tomograph II topographic parameters, diagnostic capabilities of moorfields regression analysis, and their affecting factors].

PURPOSE: To investigate optic disc topographic parameters at every stage in glaucoma patients and to compare results with data from normal Japanese subjects. We used a Heidelberg Retina Tomograph II (HRT II), to evaluate the sector diagnostic capabilities of Moorfields regression analysis in early glaucoma patients, and to determine whether there is a correlation between the background factors and either the topographic parameters or the diagnostic capabilities. SUBJECTS AND METHODS: We measured topographic parameters using HRT II, and examined static visual fields in 303 normal and 130 glaucoma eyes without high refractive error. RESULTS: Mean disc area was 2.181 +/- 0.384 mm2 in the normal Japanese subjects. At the time visual field loss first appeared, disc damage was already advanced. Moorfields regression analysis of sensitivity and specificity was 81.3% and 90.1%, respectively, for early glaucoma. The best diagnostic precision was found in the temporal/inferior sector. Correlations were noted for normal subject topographic parameters and the disc area, age, sex, and conus, but not for Moorfields regression analysis and the disc area, refractive error, age, and sex, even though diagnostic capabilities declined with the presence of conus. CONCLUSIONS: HRT II is more useful in glaucoma diagnosis than in follow-up. Focus should be on the temporal/inferior sector as well as on the overall Moorfields regression analysis. Also, close attention should be paid to the presence of conus.