Large Craniectomy Plus Edaravone in Treatment of Severe Craniocerebral Injury

Objective To evaluate clinical effect of large craniectomy combined with edaravone in the treatment of acute severe craniocerebral injury. Methods We divided 230 patients with acute severe craniocerebral injury randomly into the treatment group(n=120) and the control group(n=110). Both groups received large craniectomy for decompression and after that the treatment group was given edaravone injection 30mg in 100mL normal saline,ivgtt,bid×14d. The number of conscious patients,awakening time and GCS score in the two groups were observed and the clinical efficacy of both groups was analyzed. Results The proportion of the number of conscious patients and the GCS score after treatment in the treatment group were significantly higher than those of the control group(P0.05) and the recovery time of consciousness was shorter in the treatment group than that in the control group(P0.05). The curative rate and the total effectiveness were obviously higher in the treatment group than those in the control group(P0.05). Conclusion Large craniectomy combined with edaravone is worthy of wide application in the early stage of acute severe craniocerebral injury.