Preliminary pharmacological studies on the bioconversion product of Tripterygium wilfordii

To research the antiinflammatory and immunological pharmacology effect of bioconversion product of crude Tripterygium wilfordii(TW).Methods:The mice’ experiments of swelling of auricle induced by dimethyl benzene,weight determination of immune organs,delayed hypersensititivity reaction induced by DNFB were selected.Results:The effect of total MeOH extractive of bioconversion product was better than that of non-transformed product,especially the TW3(MeOH) extractive.The TW2(EtOAc)and TW3(EtOAc)increased thoracic gland coefficient of mouse.The TW3(DAB-6),TW3(CHCl3)and TW3(EtOAc)increased the inhibitory action on peripheral immune organs and cell immunity of mouse.Conclusion:The antiin? ammatory and immunological pharmacology effect of TW had changed after biotransformation,which indicated that the active compound basis of transformed products may be different.