Interleukin-12 induces gene expression in interleukin-2 stimulated human T lymphocytes.

INTRODUCTION Interleukin-12 (IL-12) is a heterodimeric cytokine (p70) composed of p40 and p35 subunits. IL-12 is produced by antigen-presenting cells (APC) such as dendritic cells, Langerhans cells and B cells [1]. The production of IL-12 is induced by bacteria, fungi, viruses, and their products, in a T cell-independent pathway. IL-12 is also induced in a T cell-dependent pathway via the interaction of CD40 on APC, and CD40 ligand (CD40L) [...]