Changes of serum NO and NOS in OVX rats model of osteoporosis after estrogen therapy

2002 
Objective To understand the relationship among the changes of nitric oxide(NO) and nitric oxide synthase(NOS) and osteoporosis and astrogen therapy.Methods Forty female rats were randomized into sham surgery (sham OVX) group (15) and ovariectomy(OVX) group(25).Eight weeks later,to examine the changes of NO and NOS in five OVX rats'serum and compare with five OVX rats'.The rest OVX rats were randomized control osteoporosis group(10) and estrogen group(10).After estrogen therapy eight weeks,to examin the changes of NO and NOS in estrogen group and compare with osteoporosis group and sham OVX group.Results The level of NO and NO and OVX rats were significantly lower than sham OVX rats (P0.05) .After estrogen therapy,the level of NO and NOS were significantly higher than control osteoporosis group(P0.05),and no significantly diffrence with sham OVX group(P0.05).Conclusions NO and NOS play an important role between bone formation and absorption,and estrin treatment osteoporosis may be relate to NO and NOS.
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