Estudio de la actividad simpática en el paciente con síndrome de apnea obstructiva del sueño e hipertensión arterial sistémica y valoración de la oxigenoterapia

The present prospective study longitudinal, experimental and controlled, was carried out with the purpose of analyzing the sympathetic nerve activity in the patient with OSA associated to systemic arterial hypertension. 28 subjects were studied: Group I: Constituted by 14 patients with OSA (habitual snorer with more than 5 apnea obstructive/ h), Group II: for 14 subject habitual snorers (when the subject or his wife accept that snorers 5 days a week but present less than 5 apnea obstructive/h). To all the patients were carried out complete clinical history, were made breathing functional test, prolactin, and plasmatic catecholamines and urine for chromatography liquid of high pressure, determines the pressure of the lung artery for echocardiography Doppler, as well as arterial saturation of oxygen. The patient to be hospitalized by the realization of the mentioned studies, studies that were made before and after oxygen. The administration of I oxygen was carried out through mask to 40% from 22 o’clock until the 6 hrs. daily, in the own home of patients for the lapse of 4 weeks. Results: In the group I: patient with OSA with average, IMC 25.3 + 1.0 was made studies polisomnographic demonstrating an apnea index + hipopnea inside the inferior limits of 18.7 + 10.4, the breathing functional tests showed basal restrictive pattern 70.3 + 4.7 and later to the oxygen administration the functional tests remained inside of normal parameters breathing 77.0 + 1.8 being appreciated a p < 0.05. In the group II the breathing tests remained before inside normal parameters and after the oxygen administration. In the group I the systolic pressure of the lung artery determined by echocardiography, it was elevated in their basal determination 30.4 + 9.7 for later to the administration of oxygen 26.5 + 8.6 remained inside normal pa