Comparison Between Monopolar and Bipolar Pulses for Effective Nanoporation

The utility of electric pulsing for attaining and driving a range of bio-effects have already been discussed. This chapter focuses and probes the role of pulse shape (e.g., monopolar-vs.-bipolar), multiple electrode scenarios, and serial-versus-simultaneous pulsing. A possible analysis based on a three-dimensional time-dependent continuum model is discussed. Our results indicate that monopolar pulsing always leads to higher and stronger cellular uptake. This prediction is in agreement with experimental reports and observations. It is also demonstrated that multipronged electrode configurations influence and increase the degree of cellular uptake.