The extract of Mucuna pruriens possesses histamine activity
2010
=10.0μg/ mL).(2) Diphenhydramine,an H,antagonist competitively blocked the contractile response of the Mucuna pruriens extract(3) Coadminstration of the Mucuna pruriens extract either with different doses of antimuscarinic agent atropine or 5-hydroxytryptamine blocking agent methysergide did not alter the extract induced contractile response of the guinea pig ileum.Conclusion:These results demonstrate that the spines of Mucuna pruriens possess histamine activity which may contribute to its itching and painful irritation effects.
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