Cover Picture: Eur. J. Immunol. 10/11

The cover shows human monocyte-derived macrophages migrating into gelled collagen I using the mesenchymal migration mode as described by Maridonneau–Parini and colleagues in their review (pp. 2805–2813). At the tip of the cell protrusions, 3D podosomes form and there is an elongated and protrusive cell shape, which is characteristic of this migration mode. The macrophages were fixed, permeabilized and stained with phalloidin for F-actin (green) and show accumulation of F-actin at the 3D podosomes; DAPI staining identifies the nuclei (blue). The image is a projection of five z-sections of 0.4 μm, obtained by confocal microscopy and was provided by Veronique Le Cabec.