Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice.

BACKGROUND The role of proximal tubule (PT) angiotensinogen (AGT) in modulating blood pressure has previously been examined using mice expressing PT human AGT and human renin, or rat AGT. These animals are hypertensive; however, the question remains whether alterations in mouse PT AGT alone affects arterial pressure.