Nanomedicine as a Strategy for Natural Compound Delivery to Prevent and Treat Cancers.
2016
Background: Of the >140 anticancer drugs approved since 1940 and available for
clinical application, >60% can be traced to a natural product. Of the small molecules among
them, 67% are natural in origin. Nanocarriers can be effective anticancer drug delivery systems
for preventing and treating cancers. It has been demonstrated that nanoparticles used
for drug therapy provide some advantages over conventional formulations, including increased
solubility, enhanced storage stability, improved permeability and bioavailability,
prolonged half-life, tissue targeting, and minimal side effects. Methods: In recent years, the
concept of using nanoparticles as the carriers of natural products or herbal drugs has attracted
increasing attention. This review highlights recent developments using nanomedical
approaches for natural product delivery. Results: We systematically introduce the concepts
and amelioration mechanisms of the nanomedical techniques for natural product cancer
therapy. These modalities are useful in the therapy incorporating a wide variety of natural
products for treating brain, lung, breast, and colorectal cancers. The nanosystems for biomedicine can be categorized
into three groups: polymeric, lipid, and metallic nanoparticles. All of these have been employed as anticancer
carriers for natural products. This review describes various nanocarriers loaded with natural compounds for
passive or active targeting of tumors. Conclusion: The nanomedicine research data for phytomedicine cancer
remedies suggest a way forward for generating advances in chemotherapy.
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