Synthesis of Azepino[4,5-b]indolones via an Intermolecular Radical Oxidative Substitution of N-Boc Tryptamine.

A two-step protocol for the synthesis of azepino[4,5-b]indolone derivatives featuring a xanthate radical oxidative aromatic substitution on the N-Boc protected tryptamine, using dilauroyl peroxide (DLP) as initiator and oxidant, is described.