Simultaneously Examination of P53 and C-erbB-2 in Gastroscopic Stomach Tissues

Purpose To investigate the expression of P53 and C-erbB-2 in gastroscopic Stomach Tissues for redounding to early clinical diagnosis and screening high risk population of gastric carcinomas. Methods We examined simultaneously with immunohistochemical staining ABC in 15 normal mucosa,16 mild,15 moderate,13 severe intestinal metaplasia tissues and 14 gastric carcinoma tissues. Results Immunohistochemical positive specimens of P53 and C-erbB-2 found in gastric carcinoma tissues were 8/14(57. 1 % ) and 7/14(50%) respectively. The sensitivity and specificity of immunohistochemical positive rate with double expression of C-erbB-2 and P53 were 28.6% and 100% , while that of Complex expression(C-erbB-2 and/or P53) were 84.6 % and 88.1% respectively. Conclusions C-erbB-2 can be used as a label in clinical diagnosis for gastric carcinoma because of the high specificity. Double expressin of C-erbB-2 and P53 can be used in early clinical diagnosis. Complex expression can be used to screen high risk population of gastric carcinomas.