Blocking of the fibrinolytic antiactivator by substituted benzoates

Abstract The effects of substituted benzoates on the inhibition of the urokinase-activation of profibrinolysin by the fibrinolytic antiactivator in plasma were investigated. It was found that substituted benzoates block the inhibition of urokinase by plasma fibrinolytic antiactivators. The urokinase which is bound by the antiactivator appears to be released and hence is available to activate profibrinolysin to fibrinolysin. The nitrobenzoates were the most effective of all compounds tested.