Flavonoids green tea against oxidant stress and inflammation with related human diseases

Summary The liver is the most important organ and may be regarded as the metabolic entry point of the body. It contributes the metabolism of nutrients, endobiotics and drug/xenobiotics with absolute efficacy. It performs anabolic enrichment of the larger-molecule to generate more calorific storage-materials. At the same time, catabolic end-products of hundreds of molecules are either recycled or efficiently excreted by this organ. The strongest drug-metabolizing enzymatic machinery helps this organ to fight thousands of molecules. Chronic/acute-toxicity, metabolic-syndrome, oxidative-stress, inflammatory-responses and mutagenesis carcinogenesis severely challenge this organ and make the situation life-threatening. At a severe condition during hepatitis, fatty-liver syndrome, cirrhosis, fibrotic-liver damage end-stage situation arise. Present report suggests that green tea and its constituents offer the strongest herbal remedy/therapy in liver anomalies. A large number of polyphenols with the effective galloyl group, several instaurations, hydroxyl groups and other structural specialty attribute to its antioxidant, anti-inflammatory, anti-proliferative, anti-mutagenic/anti-carcinogenic potentials. Green tea has been shown to offer its protections at cellular, biochemical and molecular levels influencing a large number of metabolic pathways.