Methylenecyclopropane Analogues of Nucleosides: Synthesis, Absolute Configuration, and Enantioselectivity of Antiviral Effect of (R)-(-)- and (S)-(+)-Synadenol

Yao-Ling Qiu,Andrew Hempel,Norman Camerman,Arthur Camerman,Geiser F,Roger G. Ptak,Julie M. Breitenbach,Toshihiko Kira,Ling Li,Elizabeth A. Gullen,Yung-Chi Cheng,John C. Drach,Jiri Zemlicka

Methylenecyclopropane Analogues of Nucleosides: Synthesis, Absolute Configuration, and Enantioselectivity of Antiviral Effect of (R)-(-)- and (S)-(+)-Synadenol

1999

Yao-Ling Qiu
Andrew Hempel
Norman Camerman
Arthur Camerman
Geiser F
Roger G. Ptak
Julie M. Breitenbach
Toshihiko Kira
Ling Li
Elizabeth A. Gullen
Yung-Chi Cheng
John C. Drach
Jiri Zemlicka

Abstract Synthesis, absolute configuration and antiviral activity of enantiomeric antiviral agents (R)-(-)- and (S)-(+)-synadenol (2 and 3a) are described.

Keywords:

Absolute configuration
Enantiomer
Nucleic acid
Methylenecyclopropane
Stereochemistry
Organic chemistry
Chemistry

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