Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes

Abstract The number of nicotinic and muscarinic receptors and choline acetyltransferase (ChAT) activity were investigated in the temporal cortex of patients with Alzheimer's disease (AD) with different apolipoprotein E (APOE) genotypes. A significant reduction in the ChAT activity ( P P ϵ 4 and ϵ 3 carriers. A significant negative correlation ( P ϵ 4 allele was not related to specific deficits in cholinergic activity in the temporal cortex of AD brains.