MiR-145 in Cancer Therapy Resistance and Sensitivity: A Comprehensive Review.

MircoRNAs (miRNAs) are a group of small, non-coding, regulatory RNAs with an average length of about 22 nucleotides, which mostly modulate gene expression post-transcriptionally via complementary binding to the 3'-untranslated region (3'-UTR) of multiple target genes. Emerging evidences have shown miRNAs are frequently dysregulated in a variety of human malignancies. Among them, microRNA-145 (miR-145) has been increasingly identified as a critical suppressor of carcinogenesis and therapeutic resistance. Resistance to tumor therapy appears as a severe and tough problem in cancer treatments due to the daunting range of resistance mechanisms. In this review, we reviewed the status quo of recent advancements of the knowledge of functional role of miR-145 in therapeutic resistance and tumor microenvironment, and it may serve as an innovative biomarker for therapeutic response and cancer prognosis.