Palladium catalyzed reductive cyclization reaction in alkaloid synthesis — an enantioselective total synthetic route to (+)-pumiliotoxin C

Abstract Beginning with the chirally homogeneous cyclohexenol 3 , an enantioselective total synthetic route to (+)-pumiliotoxin C (1) has been described. Palladium catalyzed reductive cyclization reaction was employed to prepare a key component in the synthesis.