436a Inactivation of a Single Allele of P120catenin Dramatically Accelerates KRAS-Driven Carcinogenesis in the Pancreas

ford and AIMS65) and therapeutic modality utilized to achieve hemostasis. Majority of subjects belonged to the F2A (58.0%) category, followed by F2B (24.1%) and F1B (14.3%). Only 3.6% had F1A ulcers. The majority (36.1%) had a gastroscopy within 6 hours of presentation. There were no significant differences between the two arms with regards to the above end-points. There were neither deaths (in-patient and 30 day) nor patients requiring surgery in both groups. The re-bleeding rate in the IVI group was 5.35% compared to 1.92% in the oral group, but this was not statistically significant (p=0.618). Both groups' mean hospital stay were almost the same (IVI 4.51, oral 4.50) and there was no statistically significant difference between both groups' median length of stay (p = 0.818). The transfusion requirements were also similar in both groups, an average of 1.48 units in the IVI vs. 1.86 units in the oral group (p=0.227). Conclusion These early results suggest, in patients who have received a PPI infusion pre-endoscopy, high dose oral PPI is comparable to IV PPI infusion in treating PUB post-endoscopic hemostasis with respect to re-bleeding rates, inhospital mortality, length of hospital stay, surgical intervention, transfusion requirements and 30-day mortality. Further recruitment and data collection is ongoing.